mtvU honors Frank Ocean, wounded Pakistani teen












NEW YORK (AP) — The mtvU network is honoring a rap superstar who detailed his love for another man and a Pakistani girl shot for her education advocacy as its Man and Woman of the Year.


Frank Ocean, who earned six Grammy nominations Wednesday, published a letter online about his first love, a man, just as his “channel ORANGE” disc was being released. MtvU on Thursday called it “an incredibly brave move for an artist on the verge of superstardom.”












Fifteen-year-old Malala Yousufzai (mah-LAH’-lah YOO’-suf-ZAY’) blogged about her support of education for girls in Pakistan. For that, Taliban militants stormed her school bus and shot her in the head and neck, but she survived.


The mtvU network is geared toward college students and is seen on more than 750 campuses.


Entertainment News Headlines – Yahoo! News


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Breast Cancer Vaccine a Reality for Women With HER-2 Negative Cancers












COMMENTARY | NeuVax, a breast cancer vaccine, is entering phase III trials. The drug’s manufacturer, Galena Biopharma, announced on Dec. 5, that it signed a distribution deal with TEVA Pharmaceuticals. TEVA will handle the global commercialization and distribution of the drug once it is out of trials. It is about time this is moving forward. We need to make progress toward ending this disease.


What is NeuVax?












A vaccine called NeuVax is close to being a reality for breast cancer patients. NeuVax is a vaccine, the first of its kind, to prevent breast cancer from recurring. A recurrence is when breast cancer returns to the same breast. If breast cancer appears in the other breast, it is not a recurrence but a new cancer.


Most women have a 15-20 percent chance of breast cancer recurring, even after a mastectomy. The implications of the vaccine are huge. It reduces the chance of breast cancer recurrence in women with node-positive, HER-2 negative breast cancers. About 75 percent of all breast cancer is HER-2 negative. The vaccine is given after the standard course of treatment is completed. It is not a replacement for radiation or chemotherapy. I would gladly try a vaccine over the currently available long-term recurrence preventions — all are hormone based and carry awful side effects.


Phase III trials


Unfortunately for me, there are no trials available in Arkansas. Even if there were, I am not eligible because my cancer is HER-2 positive, and I am thankfully, node-negative. This means that the cancer is not in my lymph system. Phase III trials are when the drug is actually tested in random settings on humans. This drug seems to be very promising. Right now, phase III trials are open in the United States and Canada. Israel will have at least four phase III trials opening soon. You can see if there are trials near you at the NeuVax website.


This vaccine has the potential to replace hormone therapies like tamoxifen and aromatase inhibitors. Both types of drugs have serious side effects. A vaccine, taken over the course of three years, reduces the time a patient needs to take medications and it helps to prevent recurrence. Hopefully the phase III trials go well and we get this vaccine available to breast cancer patients soon.


Lynda Altman was diagnosed with breast cancer in November 2011. She writes a series for Yahoo! Shine called “My Battle With Breast Cancer.”


Medications/Drugs News Headlines – Yahoo! News


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South Africa military plane crashes in mountains












JOHANNESBURG (AP) — A South African military aircraft on an unknown mission to an area near the village where former President Nelson Mandela lives crashed in a mountain range, officials said Thursday. It was unclear whether there were any survivors.


The Douglas DC-3 Dakota, a twin-propeller aircraft, had taken off from Pretoria’s Waterkloof Air Force Base on Wednesday night, said Brig. Gen. Xolani Mabanga, a military spokesman. On Thursday morning, soldiers found the wreckage of the airplane in the Drakensberg mountains near Ladysmith in KwaZulu-Natal province, some 340 kilometers (210 miles) southeast of the air base, Mabanga said.












Mabanga said soldiers had been sent to the scene to look for survivors. Mabanga said he did not know what the mission of the aircraft was, though it had planned to land in Mthatha in the country’s Eastern Cape. Siphiwe Dlamini, a Defense Ministry spokesman, declined to immediately comment Thursday morning.


Mthatha is about 30 kilometers (17 miles) north of Qunu, the village where Mandela now lives after retiring from public life. South Africa‘s military remains largely responsible for the former president’s medical care. However, military officials declined to say whether those on board had any part in caring for Mandela.


In November, another South African military flight crash landed at Mthatha, sending several people to the hospital with injuries. However, at that time, the military denied that those on board had anything to do with Mandela’s care.


Mandela, 94, was imprisoned for nearly three decades for his fight against apartheid before becoming the nation’s president in the country’s first fully democratic vote in 1994.


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Jon Gambrell can be reached at www.twitter.com/jongambrellAP .


Africa News Headlines – Yahoo! News


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Facebook’s Instagram cuts support for key Twitter integration












SAN FRANCISCO (Reuters) – Facebook Inc’s recently acquired photo-sharing service, Instagram, removed a key element of its integration with Twitter, signaling a deepening rift between two of the Web’s dominant social media companies.


Instagram’s Chief Executive Kevin Systrom said Wednesday his company turned off support for Twitter “cards” in order to drive Twitter users to Instagram’s own website. Twitter “cards” are a feature that allows multimedia content like YouTube videos and Instagram photos to be embedded and viewed directly within a Twitter message.












Instagram’s move marked the latest clash between Facebook and Twitter since April, when Facebook, the world’s no. 1 social network, outbid Twitter to nab fast-growing Instagram in a cash-and-stock deal valued at the time at $ 1 billion. The acquisition closed in September for roughly $ 715 million, due to Facebook’s recent stock drop.


The companies’ ties have been strained since. In July, Twitter blocked Instagram from using its data to help new Instagram users find friends.


Beginning earlier this week, Twitter’s users began to complain in public messages that Instagram photos did not seem to display properly on Twitter’s website.


Instagram CEO Kevin Systrom confirmed Wednesday that his company had decided that its users should view photos on Instagram’s own Web pages and took steps to change its policies.


“We believe the best experience is for us to link back to where the content lives,” Systrom said in a statement, citing recent improvements to Instagram’s website.


“A handful of months ago, we supported Twitter cards because we had a minimal web presence,” Systrom said, noting that the company has since released new features that allow users to comment about and “like” photos directly on Instagram’s website.


The move escalates a rivalry in the fast-growing social networking sector, where the biggest players have sought to wall off access to content from rival services and to their ranks of users. Photos are among the most popular features on both Facebook and Twitter, and Instagram’s meteoric rise in recent years has further proved how picture-sharing has become a key front in the battle for social Internet supremacy.


Instagram, which has 100 million users, allows consumers to tweak the photos they take on their smartphones and share the images with their friends, a feature that Twitter has reportedly also begun to develop. Twitter’s executive chairman Jack Dorsey was an investor in Instagram and hoped to acquire it before Facebook CEO Mark Zuckerberg tabled a successful bid.


When Zuckerberg announced the acquisition in an April blog post, he said one of Instagram’s strengths was its inter-connectivity with other social networks and pledged to continue running it as an independent service.


“We think the fact that Instagram is connected to other services beyond Facebook is an important part of the experience,” Zuckerberg wrote. “We plan on keeping features like the ability to post to other social networks.”


A Twitter spokesman declined comment Wednesday, but a status message on Twitter’s website confirmed that users are “experiencing issues,” such as “cropped images” when viewing Instagram photos on Twitter.


Systrom noted that Instagram users will be able to “continue to be able to share to Twitter as they originally did before the Twitter Cards implementation.”


(Reporting By Alexei Oreskovic and Gerry Shih; Editing by Nick Zieminski)


Social Media News Headlines – Yahoo! News


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Jazz pianist Dave Brubeck dead at 91












NEW YORK (Reuters) – Jazz pianist Dave Brubeck, whose choice of novel rhythms, classical structures and brilliant sidemen made him a towering figure in modern jazz, has died at the age of 91, his longtime manager and producer Russell Gloyd said on Wednesday.


Brubeck died of heart failure on Wednesday morning after he fell ill on his way to a regular medical exam at Norwalk Hospital, in Norwalk, Conn., a day short of his 92nd birthday, Gloyd said.












His Dave Brubeck Quartet put out one of the best selling jazz songs of all time: “Take Five,” composed by alto saxophonist Paul Desmond. Like many of the group’s works, it had an unusual beat — 5/4 time as opposed to the usual 4/4.


“We play it differently every time we play it,” Brubeck told The Philadelphia Inquirer in 2005. “So I never get tired of playing it. That’s the beauty of jazz.”


“Take Five” was the first million-selling jazz single.


Dressed in a suit and horn-rimmed glasses and living a clean-cut lifestyle in the 1950s, Brubeck did not fit the stereotype of a hipster jazzman and his music was not nearly as brooding as that coming from East Coast be-bop players.


Despite his innovative approach, some critics interpreted Brubeck’s popularity as a sign of un-coolness, but his fans were undeterred.


Brubeck was born in Concord, California, on December 6, 1920. His father was a rancher and as a teenager Brubeck was a skilled cowboy. But his mother, a music teacher who had five pianos in the house, saw that he took up piano at age 5.


At the College of the Pacific in Stockton, California, he planned to be a veterinarian, but within a year he was majoring in music and playing jazz in nightclubs.


“After my first year in veterinary pre-med I switched to the music department … and that was at the advice of my zoology teacher,” Brubeck said in a Reuters interview. “He said ‘Brubeck, your mind is not here, with these frogs and formaldehyde. Your mind is across the lawn at the conservatory. Will you please go over there.’”


Brubeck later met the co-director of a weekly campus radio show, Iola Marie Whitlock, and they eventually married.


After graduation, Brubeck studied under French composer Darius Milhaud and played in a U.S. Army jazz band during World War Two.


In the late 1940s, he moved to the San Francisco Bay area, where he headed an experimental jazz octet. He formed a trio in 1950 and the following year expanded to a quartet with Desmond, who he had known since the war.


Brubeck injected classical counterpoint, atonal harmonies and modern dissonance into his music, hinting at composers such as Debussy, Bartok, Stravinsky and Bach.


The group built an enduring fan base by taking its subdued bluesy brand of classically influenced jazz to colleges.


As a leading figure in the West Coast jazz scene, which also included Gerry Mulligan and Chet Baker, Brubeck was featured in a Time magazine cover story in 1954. Some critics and black musicians, who felt jazz was a central part of black culture, resented the story about the prominence of a white artist.


In the article Brubeck said Milhaud had told him “if I didn’t stick to jazz, I’d be working out of my own field and not taking advantage of my American heritage.”


Brubeck disbanded the quartet in 1967 after nearly 17 years to concentrate on composing. He wrote several choral works, all religiously influenced.


He later began performing jazz regularly again and appeared with his sons, Darius, a composer and pianist; Chris, who played electric bass and trombone; and drummer Danny. They were billed as Two Generations of Brubeck.


In February 1989 Brubeck, who had a history of heart problems, underwent triple-bypass surgery but kept playing. Well into his 80s, he still put on some 80 shows a year. He had a pacemaker implanted in October 2010.


Actor-director Clint Eastwood, a jazz fan, announced plans to make a documentary on Brubeck in 2007. Eastwood also was named chairman of the Brubeck Institute at the University of the Pacific, designated as the home of his papers, private recordings and other memorabilia.


Brubeck and his wife, who also was his agent and lyricist, had two other sons, Matthew, a cellist, and Michael, and a daughter, Catherine. The couple lived in Wilton, Connecticut.


(Reporting by Christine Kearney; Editing by Leslie Gevirtz)


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With Teva at crossroads, new CEO set to unveil vision












NEW YORK/TEL AVIV (Reuters) – Teva Pharmaceutical Industries‘ new Chief Executive Jeremy Levin has promised investors it will be a very different company going forward. Next week he has to prove it.


Levin’s ability to paint a bright future for the world’s biggest maker of generic drugs at a meeting with investors and analysts on December 11 in New York became a bit more difficult last week, when Teva issued a 2013 earnings forecast that fell short of Wall Street estimates.












Levin, a big pharma veteran, is expected to shift Teva’s focus to branded drugs even as its most important such product, top-selling multiple sclerosis treatment Copaxone, faces new competition and a 2015 patent expiration. Investors are also hoping for a meaningful boost to the annual dividend while new management works to jumpstart a stagnant share performance.


“I’ve made a lot of money in Teva and I’ve seen this company wither in front of my eyes,” said Dan Hunt, a co-portfolio manager for RCM Capital Management’s Wellness Fund. Hunt’s fund no longer includes Teva shares, but RCM has small Teva holdings.


“The most important signal (shareholders) need to hear on the record from Levin is ‘whatever it takes I will protect you’,” Hunt said, adding that Teva has not delivered for its shareholders in years.


Teva’s U.S. shares are up about 2 percent in 2012 after falling 22.6 percent in 2011. They are off 35 percent from a 2010 peak at about $ 64. Shareholders of smaller Teva rivals Watson Pharmaceuticals Inc and Mylan Inc have fared far better with Watson up about 45 percent this year and Mylan shares up about 27 percent over the same period.


Levin has taken some preemptive steps to placate investors ahead of the meeting by announcing that the company plans to cut $ 1.5 billion to $ 2 billion in costs over the next five years, streamline operations and discontinue some research programs.


Morgan Stanley estimated that Copaxone sales account for 58 percent of Teva’s projected 2013 earnings. Levin will have to reveal how he plans to make up for the anticipated decline in Copaxone revenue beyond cost-cutting efforts.


Generic drugs accounted for 56 percent of Teva’s revenue last year, but the company faces obstacles to generic growth in the United States, the world’s largest market.


Following a wave of major patent expirations, the number of multibillion-dollar drugs going generic will diminish after the next couple of years. And new generic drugs are facing competition sooner along with faster price declines. Generic drugs are also facing considerable price pressure in Europe.


SMALL ACQUISITIONS


South African-born Levin, a former senior vice president for strategy at Bristol-Myers Squibb Co, took over as CEO of Israel’s biggest company in May, replacing Shlomo Yanai.


In five years at the helm, Yanai engineered a number of large acquisitions, including last year’s $ 6.5 billion purchase of U.S. drugmaker Cephalon, which has been viewed by some analysts as a disappointment. The company last month took a $ 481 million impairment charge related to the Cephalon deal.


Levin last week signaled a desire for more targeted acquisitions focused on Teva’s core areas of expertise, such as central nervous system disorders and respiratory diseases.


He has begun to whittle away at non-core businesses, selling Teva’s U.S. animal health unit to Bayer for up to $ 145 million. Investors said Teva needs to improve production efficiency and downsize or close some of its plants.


Levin, who implemented at Bristol-Myers a series of deals and alliances with small and large companies, has been credited with helping to guide Bristol through its enormous patent cliff as the blood clot preventer Plavix, which had been the world’s second biggest selling prescription medicine, lost exclusivity.


“The key is smart deals and getting an estimate of what a reasonable growth rate is going forward,” said Robert Caravella, equity research analyst for Victory Capital Management, which holds about $ 9 million in Teva convertible bonds.


“The biggest issue is there’s not an understanding of where revenue and earnings are going to go and how we’re going to get to that point,” he said.


BIGGER DIVIDEND?


Shareholders would also like to see Teva raise its dividend, which provides only a 2.5 percent return on the stock, below the industry average of about 4 percent. Alternatively, the company may decide to increase shareholder returns by boosting its $ 3 billion share buyback.


Steven Tepper, an analyst at brokerage Harel Finance, said Levin must demonstrate how Teva can again become a growth company or that it will be a value investment going forward through a significant dividend increase. “This plan will have to convince investors it’s making that move,” Tepper said.


RCM Capital’s Hunt said Levin must present “a strong, formed, clear strategic vision” of where the company is headed.


The question is whether it will be enough to convince disenchanted investors such as Stewart Capital, which has more than $ 1 billion in assets under management but sold its Teva holdings shortly after Levin took over.


Matthew DiFilippo, chief portfolio strategist for Stewart, was skeptical that one individual could effect the change necessary to transform Teva back into an industry darling. “So while we recognized his talents, we also recognized the challenges they face and we sold,” he said.


A lot of money remains on the sidelines waiting for what Levin has to say, said Ori Hershkovitz, managing partner at Israel-based pharmaceutical hedge fund Sphera. Levin needs to say he is committed to replenishing Teva’s branded pipeline and will do whatever it takes to replace those lost sales by 2016, Hershkovitz said, and he must “make the market believe it”.


(Additional reporting by Steven Scheer in Jerusalem; Editing by Leslie Gevirtz)


Medications/Drugs News Headlines – Yahoo! News


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Sri Lanka see backlash from Aussie ‘wounded soldiers’












(Reuters) – Sri Lanka captain Mahela Jayawardene has warned his team to be wary of a backlash from Australia in their three-test series after the hosts were stung by their series defeat to South Africa earlier this week.


Australia’s hopes of snatching the Proteas’ top test ranking ended in a crushing 309-run defeat in the third and final test in Perth on Monday, but Jayawardene took little comfort from the home side’s disappointment.












“I see them as wounded soldiers – they could come back stronger against us,” Jayawardene told reporters in Canberra on Wednesday, on the eve of a three-day tour match against a Chairman’s XI side.


“So we just need to make sure we are ready for that and start well.


“We can’t be complacent – we need to make sure we know from ball one we give them a good go at it.”


Sri Lanka have their own problems coming into the first test at Hobart next week, losing their last test at home to New Zealand by 167 runs to level a two-match series 1-1, with key batsmen out of form.


Kumar Sangakkara scored five, nought and 16 in his three innings against New Zealand, but Jayawardene backed the veteran to bounce back in Sri Lanka’s bid to win their first test Down Under.


“I am happy that he went through a lean phase because he’ll be really hungry for runs – that’s Kumar for you,” Jayawardene said of the 35-year-old stalwart.


Jayawardene also said he would weigh up his future as captain after the series, which includes tests in Melbourne and Sydney, after taking on the role for a second time in the wake of Tillakaratne Dilshan’s sudden resignation in January.


“After this, we get a well-deserved four weeks off, after about three years, so it gives me a bit of time to think (about) what I need to do,” said Jayawardene, who captained the team for more than three years in his first stint from 2006.


“We need to groom another leader as well. It’s very important to have that changeover done smoothly while the senior players are still in the side.”


Australia / Antarctica News Headlines – Yahoo! News


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Citigroup in 11,000 staff cull













Citigroup says it is cutting 11,000 jobs worldwide in an efficiency drive, with most of the jobs being lost in its consumer banking division.












The bank said the move, which will see its headcount shrink by 4%, would cost it about $ 1bn (£621m) in pre-tax charges.


Shares in the bank rose 7% following the announcement.


The move comes two months after the bank’s former chief executive, Vikram Pandit, suddenly resigned.


Michael Corbat took over from Mr Pandit as chief executive.


The bank said the $ 1bn charge would be recorded in its fourth-quarter figures for this year.


It said it would also add another $ 100m in charges to the first half profits for 2013.


Citigroup said the changes would leave it $ 900m better off in 2013 and a further $ 1.1bn the following year.


The company said that about 25% of the charges for the fourth quarter related to its securities and banking division, with another 10% in transaction services.


Another third would come from reductions in its global consumer banking division, where 6,200 positions would be cut.


Moving out


The banking group said it would be selling or scaling back consumer operations in Pakistan, Paraguay, Romania, Turkey and Uruguay.


Other countries affected by the changes would be Brazil, Hong Kong, Hungary, South Korea and the US.


It is also closing branches in Greece and Spain, countries hard-hit by the eurozone crisis.


It intends to focus on the 150 cities that have the highest growth potential in consumer banking.


After the changes, Citi said it would have more than 4,000 retail branches around the world.


At the time of Mr Pandit’s sudden departure, the bank’s chairman, Michael O’Neill, said the departure was not due to any “strategic, regulatory or operating issue”.


Mr Pandit left the bank with a settlement of more than $ 15m.


He resigned a day after Citi reported an 88% drop in quarterly profits to $ 468m.


BBC News – Business


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China goes crazy for iPhone 5: Preorders hit 100,000 units in under 24 hours












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Longtime editor at DC’s Vertigo imprint leaving












PHILADELPHIA (AP) — DC Entertainment says its executive editor and senior vice president of Vertigo — a groundbreaking imprint whose titles have included “Hellblazer,” ”DMZ” and “Sandman” — is leaving early next year.


Karen Berger will step down in March after nearly 20 years at the helm, saying in a statement released by DC late Monday that she is ready for a professional change.












During her tenure at Vertigo, the imprint saw a wide range of writers and artists — Neil Gaiman, Jill Thompson, Becky Cloonan and Brian Wood, among them — who produced titles beyond the traditional superhero and villain archetype.


Gerard Way of My Chemical Romance and writer of “The Umbrella Academy” tweeted that Berger gave “us weird kids in high school a Sub Pop Records for comics.”


___


Online:


http://www.vertigocomics.com


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