As Conn. story unfolds, media struggle with facts






NEW YORK (AP) — The scope and senselessness of the Newtown, Conn., school shooting challenged television journalists’ ability to do much more than lend, or impose, their presence on the scene.


Pressed with the awful urgency of the story, TV, along with other media, fell prey to reporting “facts” that were often in conflict or wrong.






How many people were killed? Which Lanza brother was the shooter: Adam or Ryan? Was their mother, who was among the slain, a teacher at the school?


Like the rest of the news media, television outlets were faced with intense competitive pressures and an audience ravenous for details in an age when the best-available information was seldom as reliable as the networks’ high-tech delivery systems.


Here was the normal gestation of an unfolding story. But with wall-to-wall cable coverage and second-by-second Twitter postings, the process of updating and correcting it was visible to every onlooker. And as facts were gathered by authorities, then shared with reporters (often on background), a seemingly higher-than-usual number of points failed to pan out:


— The number of dead was initially reported as anywhere from the high teens to nearly 30. The final count was established Friday afternoon: 20 children and six adults, as well as Lanza’s mother and the shooter himself.


— For hours on Friday, the shooter was identified as Ryan Lanza, with his age alternatively reported as 24 or 20. The confusion seemed partly explainable when it was determined that 20-year-old Adam Lanza, the shooter who had then killed himself, was carrying identification belonging to his 24-year-old brother.


This case of mistaken identity was painfully reminiscent of the Atlanta Olympics bombing case in 1996, when authorities fingered an innocent man, and the news media ran with it, destroying his life. Such damage was averted in Ryan Lanza’s case largely by his public protestations on social media, repeatedly declaring “It wasn’t me.”


— Initial reports differed as to whether Lanza’s mother, Nancy, was shot at the school, where she was said to be a teacher, or at the home she shared with Adam Lanza. By Friday afternoon, it was determined that she had been shot at their home.


Then doubts arose about whether Nancy Lanza had any link to Sandy Hook Elementary. At least one parent said she was a substitute teacher, but by early Saturday, an official said investigators had been unable to establish any connection with the school.


That seemed to make the massacre even more confusing. Early on, the attack was said to have taken place in her own classroom and was interpreted by more than one on-air analyst as possibly a way for Adam Lanza to strike back at children with whom he felt rivalry for his mother’s affection.


— Lanza’s weapons were listed as two pistols (a Glock and a Sig Sauer) as well as a .223-caliber Bushmaster rifle, but whether that rifle was used in the school or left in the trunk of Lanza’s car remained unclear.


— There were numerous versions of what Lanza was wearing, including camouflage attire and black paramilitary garb.


With so many unanswered questions, TV correspondents were left to set the scene and to convey the impact in words that continually failed them.


However apt, the phrase “parents’ worst nightmare” became an instant cliche.


And the word “unimaginable” was used countless times. But “imagine” was exactly what the horrified audience was helpless not to do.


The screen was mostly occupied by grim or tearful faces, sparing everybody besides law enforcement officials the most chilling sight: the death scene in the school, where — as viewers were reminded over and over — the bodies remained while evidence was gathered. But who could keep from imagining it?


Ironically, perhaps the most powerful video came from 300 miles away, in Washington, where President Barack Obama delivered brief remarks about the tragedy. His somber face, the flat tone of his voice, the tears he daubed from his eyes, and his long, tormented pauses said as much as his heartfelt words. He seemed to speak for everyone who heard them.


But TV had hours to fill.


Children from the school were interviewed. It was a questionable decision for which the networks took heat from media critics and viewers alike. But the decision lay more in the hands of the willing parents (who were present), and there was value in hearing what these tiny witnesses had to say.


“We had to lock our doors so the animal couldn’t get in,” said one little boy, his words painting a haunting picture.


In the absence of much hard information, speculation was a regular fallback. Correspondents and other “experts” persisted in diagnosing the shooter, a man none of them had ever met or even heard of until hours earlier.


CNN’s “Piers Morgan Tonight” scored an interview with a former classmate of Lanza’s — with an emphasis on “former.”


“I really only knew him closely when we were very, very young, in elementary school together,” she said.


Determined to unlock Lanza’s personality, Morgan asked the woman if she “could have ever predicted that he would one day flip and do something as monstrous as this?”


“I don’t know if I could have predicted it,” she replied, struggling to give Morgan what he wanted. “I mean, there was something ‘off’ about him.”


The larger implications of the tragedy were broached throughout the coverage — not least by Obama.


“We’re going to have to come together and take meaningful action to prevent more tragedies like this, regardless of the politics,” he said, which may have gladdened proponents of stricter gun laws.


But CBS correspondent Nancy Cordes noted, “There’s often an assumption that after a horrific event like this, it will spark a fierce debate on the issue. But in recent years, that hasn’t been the case.”


Appearing on “The O’Reilly Factor” Friday night, Fox News correspondent Geraldo Rivera voiced his own solution.


“I want an armed cop at every school,” he said.


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School murders silence “cliff” rhetoric as deadline nears






WASHINGTON (Reuters) – Mass murder in Connecticut silenced “fiscal cliff” talk on Saturday as the White House and Congress quietly got ready for a final scramble to avert the tax hikes and spending cuts set for the New Year, with sessions of the U.S. House of Representatives now scheduled just days before Christmas.


President Barack Obama canceled a trip he had planned to make next Wednesday to Portland, Maine to press his case for tax hikes for the wealthy. His weekly radio and Internet address on Saturday focused on Newtown, the site of Friday’s school shootings, in which a gunman killed 20 children and six adults before taking his own life.






House Speaker John Boehner of Ohio canceled the standard Republican radio response to Obama “so that President Obama can speak for the entire nation at this time of mourning,” he said in a statement issued late Friday.


The moratorium on cliff pronouncements masked a growing recognition that the two sides could remain deadlocked at the end of the year on the key sticking point – whether to leave low tax rates in place except for high earners, as Obama wants, or extend them for all taxpayers, as Boehner wants.


With multiple polls showing that the public supports Obama’s position, Republicans in the U.S. Senate prodded their counterparts in the House to make a face-saving retreat, in a fashion that would allow Obama’s proposal to pass the Republican-controlled House while simultaneously letting Republicans cast a vote against it.


Republicans could then shift the debate onto territory they consider more favorable to them, cutting government spending to reduce the deficit.


“Just about everyone is throwing stuff on the wall to see if anything sticks,” one Republican aide said with reference to various proposals being discussed on how to proceed. Alluding to public opinion polls, the aide added: “We know if there is no deal, we will get blamed.”


“We could win the argument on spending cuts,” said a Republican senator who asked not to be identified. “We aren’t winning the argument on taxes.”


However, Republican leaders in both chambers are leery about seeming to cave on taxes. “There’s concern that if we did that, Obama would simply declare victory and walk away and not address spending,” said one aide. “We don’t trust these guys.”


Some of the prodding was coming from Senate Minority Leader Mitch McConnell of Kentucky.


Don Stewart, a McConnell spokesman, said the minority leader in the Democratic-controlled Senate hasn’t embraced any single plan, but has discussed and circulated measures offered by fellow Senate Republicans.


“Senator McConnell does not advocate raising taxes on anybody or anything,” Stewart said.


“We’re focused on getting a balanced plan from the White House that will begin to solve the problem of our debt and deficit to improve the economy and create American jobs,” said Boehner spokesman Michael Steel.


“Right now, all the president is offering is massive tax hikes with little or no spending cuts and reforms,” Steel said.


House Majority Leader Eric Cantor scheduled “possible legislation related to expiring provisions of law,” a reference to the expiring tax cuts, for the end of the week, portending a weekend session.


Cantor has said the House would meet through the Christmas holidays and beyond.


Hopes expressed after the November6 general election of some “grand bargain” on deficit reduction have all but disappeared, at least for this year. This is partly because time is running out and partly result of growing warnings from Democrats in Congress that they would not support big changes in the Medicare program, the government-run health insurance program for seniors that is a major contributor to the government’s debt.


House Democratic Minority Leader Nancy Pelosi of California ruled out one frequently mentioned proposal – raising the age of eligibility for Medicare, in a December 12 CBS television interview.


Asked if she was drawing a “red line,” around that idea, Pelosi said her comments were “something that says, ‘don’t go there,’ because it doesn’t produce money.


(Reporting by Thomas Ferraro and Kim Dixon; Editing by Fred Barbash and David Brunnstrom)


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US prices fall on cheaper petrol







US consumers prices fell in November due to a sharp drop in petrol prices, according to official figures, as inflation in the economy remained weak.






The consumer price index fell 0.3% from October, the first decline since May, the US Labor Department said.


The gasoline index fell 7.4% in November, which more than offset gains in prices elsewhere.


Stripping out food and energy costs, “core” prices rose by 0.1% in November, the figures showed.


Over the past year, consumer prices have risen 1.8%, while core prices have increased by 1.9%.


The US economy remains fragile and, earlier this week, the US central bank pledged to continue buying bonds to keep actual borrowing rates low until the labour market outlook improves substantially.


Though the unemployment rate fell to a four-year low of 7.7% in November, statistics suggest that much of the decline in the jobless rate since 2008 has been due to people dropping out of the workforce, either due to retirement or because they have given up seeking work.


The Federal Reserve also cut its economic outlook. It now expects the economy to grow between 1.7-1.8% this year, down from 1.7-2.0% it previously expected.


The latest data came against the backdrop of the looming “fiscal cliff” – the tax increases and spending cuts due to be implemented in January if Congress and the White House do not strike a deal.


The Fed chief said last month that all of the changes would “pose a substantial threat to the recovery”.


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Xbox 720 and PlayStation 4 might not launch until 2014






Nintendo (NTDOY) says its kickstarted the next generation of video game consoles with the Wii U. But considering its graphics and processing power are comparable to Microsoft’s (MSFT) Xbox 360 and Sony’s (SNE) PlayStation 3, hardcore gamers are holding out for the next Xbox, tentatively dubbed “Xbox 720,” and next-generation PlayStation, tentatively called PS4. Rumors insist Microsoft and Sony will both launch their next consoles in the fall of 2013, but SemiAccurate, the website that first reported the next Xbox could see a delay, says there is a bit of confusion over how the consoles are progressing and when they’ll arrive.


According to SemiAccurate, the next Xbox is currently code-named “Kryptos” and not “Durango” anymore, and the next PlayStation is now code-named “Thebes” rather than “Orbis.” The PS4 will reportedly have a 28-nanometer AMD chipset and will be produced by IBM or Global Foundries.






SemiAccurate says the PS4 could be released in spring of 2014 or fall 2014 and the Xbox 720 could still see the delay from fall 2013 to 2014.


Xbox World claimed last month that the next Xbox will have a Blu-ray disc drive, Kinect 2.0, directional audio, TV output and input, an “innovative controller” and support for augmented reality glasses – all packaged in a magnesium alloy shell that will supposedly use the same patented “VaporMg” process found on the Surface tablet.


Not only that, but Microsoft is also working on an “Xbox Lite,” according to reports from earlier this year.


As for PS4 details, VG247 reported in November that Sony has already sent out various developer kits with specs including 16GB of RAM and 256GB of storage.


Sony and Microsoft are expected to reveal their next consoles at E3 2013 this coming June.


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“X Factor” judge L.A. Reid quitting TV talent show






LOS ANGELES (Reuters) – L.A. Reid, “The X Factor” judge, says he is leaving the TV talent show next season after two years on the panel.


Reid, 56, chairman and chief executive of Epic Records, told “Access Hollywood,” the television program and website, he has decided to leave the Fox reality singing show to return to the record label full time.






“I have decided that I will not return to ‘The X Factor’ next year,” Reid told “Access Hollywood” late Thursday. “I have to go back and I have a company to run that I’ve kind of neglected, and it saddens me a little bit, but only a little bit.”


He added that the show was “a nice break, it was a nice departure from what I’ve done for the past 20 years, but now I gotta go back to work.”


Fox declined to comment on Reid’s departure on Friday.


Reid joined “The X Factor” when Cowell introduced the show in the United States in September 2011. Reid sat alongside Paula Abdul, former Pussycat Dolls singer Nicole Scherzinger and Cowell.


Cowell fired Abdul and Scherzinger after a disappointing first season and brought in pop stars Britney Spears and Demi Lovato.


But “The X Factor” audiences have dropped this year to an average 9.7 million from about 12.5 million an episode in 2011.


The show broadcasts a two-part finale next week with the winner earning a $ 5 million prize and record contract.


Epic Records, a unit of Sony Music Entertainment, which commands a roster of artists including Avril Lavigne, will sign the winners of “The X Factor.”


(Reporting by Piya Sinha-Roy; editing by Jill Serjeant and Jeffrey Benkoe)


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U.S. to finalize stricter soot standards on Friday






WASHINGTON (Reuters) – The Obama administration will finalize stronger limits on harmful soot pollution from power plants and diesel engines on Friday, two health groups said.


The new standards, which the Environmental Protection Agency was under court order to finalize, will limit annual average soot emissions to about 12 micrograms per cubic meter of air from the standard of 15 micrograms set in 1997, the groups said.






Individual states will be responsible for deciding how to limit the emissions of fine particulates, which can threaten the elderly, people with heart disease and children.


When the EPA proposed the rules in June it said only six counties in California, Arizona, Alabama, Michigan and Montana are out of compliance with the standard. It also said the reduction in health bills from the standard would far outweigh the costs to industry.


(Reporting by Timothy Gardner; Editing by Gerald E. McCormick and Bob Burgdorfer)


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Fiat CEO: plan to buy Chrysler shares






NEW YORK (Reuters) – Italian carmaker Fiat SpA fully intends to acquire the 41.5 percent of Chrysler Group shares that it does not now own, but wrangling over the price could continue for a while, Fiat-Chrysler chief Sergio Marchionne said on Friday.


Fiat is in arbitration proceedings with the owner of the shares, a United Auto Workers trust fund that pays medical benefits to retired workers. The trust fund acquired the shares during the U.S. government-sponsored bankruptcy and bailout of Chrysler in 2009, when Fiat gained an ownership stake and management control of the U.S. automaker.






“We’ve always taken the position that we would have to pay them, but the question is price,” said Marchionne, speaking on the sidelines of a meeting of the Council for the United States and Italy, an international-relations group. The current arbitration proceedings, he added, are “part of the dance”.


If, as industry experts predict, the two sides cannot agree on a price by year-end, the trust fund can begin the process that would lead to an initial public offering of its shares, potentially depriving Fiat of its goal of gaining full ownership of Chrysler.


However, the IPO process would take months to meet regulatory and other requirements, and a settlement could be reached during that time.


UBS estimates the fair value of Chrysler at between $ 9 billion and $ 13.4 billion, meaning the trust fund’s 41.5 percent stake is worth between $ 4.1 billion and $ 5.5 billion.


Fiat and the health care trust are battling in a Delaware court over a 3.32 percent piece of Chrysler. Fiat is able to purchase up to 16.4 percent of Chrysler in this piecemeal fashion over the next three-and-a-half years. Chrysler has offered about half of what the health care trust believes the 3.32 percent stake is worth.


When Chrysler exited its 2009 bankruptcy, Fiat took a 20-percent ownership and has increased that since to the current 58.5 percent of the No. 3 U.S. automaker.


The system for Fiat to buy tranches of Chrysler for a total of 16.4 percent of the U.S. automaker was also part of that bankruptcy agreement. Fiat says it has used a formula for setting its price for the first tranche of those shares, and the trust wants more than double that figure. The full 16.4 percent of Chrysler to be purchased in this manner would total, Fiat says, $ 754 million, while the trust wants $ 1.7 billion.


Fiat earlier rebutted a report that it was set to raise money to finance its purchase of a further stake in Chrysler, saying it had no need for extra funds.


Its comment came after an unsourced report in Il Messaggero said Fiat was sounding out UniCredit , Morgan Stanley , Bank of America and Goldman Sachs about the possibility of raising between 1 and 2 billion euros ($ 1.3-$ 2.6 billion).


(Reporting by Paul Ingrassia; Editing by Dale Hudson)


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Selling flak jackets in the cyberwars






SAN FRANCISCO (Reuters) – When the Israeli army and Hamas trade virtual blows in cyberspace, or when hacker groups like Anonymous rise from the digital ether, or when WikiLeaks dumps a trove of classified documents, some see a lawless Internet.


But Matthew Prince, chief executive at CloudFlare, a little-known Internet start-up that serves some of the Web’s most controversial characters, sees a business opportunity.






Founded in 2010, CloudFlare markets itself as an Internet intermediary that shields websites from distributed denial-of-service, or DDoS, attacks, the crude but effective weapon that hackers use to bludgeon websites until they go dark. The 40-person company claims to route up to 5 percent of all Internet traffic through its global network.


Prince calls his company the “Switzerland” of cyberspace – assiduously neutral and open to all comers. But just as companies like Twitter, YouTube and Facebook have faced profound questions about the balance between free speech and openness on the Internet and national security and law enforcement concerns, CloudFlare‘s business has posed another thorny question: what kinds of services, if any, should an American company be allowed to offer designated terrorists and cyber criminals?


CloudFlare’s unusual position at the heart of this debate came to the fore last month, when the Israel Defense Forces sought help from CloudFlare after its website was struck by attackers based in Gaza. The IDF was turning to the same company that provides those services to Hamas and the al-Quds Brigades, according to publicly searchable domain information. Both Hamas and al-Quds, the military wing of the Palestinian Islamic Jihad, are designated by the United States as terrorist groups.


Under the USA Patriot Act, U.S. firms are forbidden from providing “material support” to groups deemed foreign terrorist organizations. But what constitutes material support – like many other facets of the law itself – has been subject to intense debate.


CloudFlare’s dealings have attracted heated criticism in the blogosphere from both Israelis and Palestinians, but Prince defended his company as a champion of free speech.


“Both sides have an absolute right to tell their story,” said Prince, a 38-year old former lawyer. “We’re not providing material support for anybody. We’re not sending money, or helping people arm themselves.”


Prince noted that his company only provides defensive capabilities that enable websites to stay online.


“We can’t be sitting in a role where we decide what is good or what is bad based on our own personal biases,” he said. “That’s a huge slippery slope.”


Many U.S. agencies are customers, but so is WikiLeaks, the whistle-blowing organization. CloudFlare has consulted for many Wall Street institutions, yet also protects Anonymous, the “hacktivist” group associated with the Occupy movement.


Prince‘s stance could be tested at a time when some lawmakers in the United States and Europe, armed with evidence that militant groups rely on the Web for critical operations and recruitment purposes, have pressured Internet companies to censor content or cut off customers.


Last month, conservative political lobbies, as well as seven lawmakers led by Ted Poe, a Republican from Texas, urged the FBI to shut down the Hamas Twitter account. The account remains active; Twitter declined to comment.


MATERIAL SUPPORT


Although it has never prosecuted an Internet company under the Patriot Act, the government’s use of the material support argument has steadily risen since 2006. Since September 11, 2001, more than 260 cases have been charged under the provision, according to Fordham Law School’s Terrorism Trends database.


Catherine Lotrionte, the director of Georgetown University’s Institute for Law, Science and Global Security and a former Central Intelligence Agency lawyer, argued that Internet companies should be more closely regulated.


“Material support includes web services,” Lotrionte said. “Denying them services makes it more costly for the terrorists. You’re cornering them.”


But others have warned that an aggressive government approach would have a chilling effect on free speech.


“We’re resurrecting the kind of broad-brush approaches we used in the McCarthy era,” said David Cole, who represented the Humanitarian Law Project, a non-profit organization that was charged by the Justice Department for teaching law to the Kurdistan Workers’ Party, which is designated by the United States as a terrorist group. The group took its case to the Supreme Court but lost in 2010.


The material support law is vague and ill-crafted, to the point where basic telecom providers, for instance, could be found guilty by association if a terrorist logs onto the Web to plot an attack, Cole said.


In that case, he asked, “Do we really think that AT&T or Google should be held accountable?”


CloudFlare said it has not been contacted about its services by the U.S. government. Spokespeople for Hamas and the Palestinian Islamic Jihad, told Reuters they contracted a cyber-security company in Gaza that out-sources work to foreign companies, but declined to comment further. The IDF confirmed it had hired CloudFlare, but declined to discuss “internal security” matters.


CloudFlare offers many of its services for free, but the company says websites seeking advanced protection and features can see their bill rise to more than $ 3,000 a month. Prince declined to discuss the business arrangements with specific customers.


While not yet profitable, CloudFlare has more than doubled its revenue in the past four months, according to Prince, and is picking up 3,000 new customers a month. The company has raked in more than $ 22 million from venture capital firms including New Enterprise Associates, Venrock and Pelion Venture Partners.


Prince, a Midwestern native with mussed brown hair who holds a law degree from the University of Chicago, said he has a track record of working on the right side of the law.


A decade ago, Prince provided free legal aid to Spamhaus, an international group that tracked email spammers and identity thieves. He went on to create Project Honey Pot, an open source spam-tracking endeavor that turned over findings to police.


Prince’s latest company, CloudFlare, has been hailed by groups such as the Committee to Protect Journalists for protecting speech. Another client, the World Economic Forum, named CloudFlare among its 2012 “technology pioneers” for its work. But it also owes its profile to its most controversial customers.


CloudFlare has hosted 4Chan, the online messaging community that spawned Anonymous. LulzSec, the hacker group best known for targeting Sony Corp, is another customer. And since last May, the company has propped up WikiLeaks after a vigilante hacker group crashed the document repository.


Last year, members of the hacker collective UgNazi, whose exploits include pilfering user account information from eBay and crashing the CIA.gov website, broke into Prince’s cell phone and email accounts.


“It was a personal affront,” Prince said. “But we never kicked them off either.”


Prince said CloudFlare would comply with a valid court order to remove a customer, but that the Federal Bureau of Investigation has never requested a takedown. The company has agreed to turn over information to authorities on “exceedingly rare” occasions, he acknowledged, declining to elaborate.


“Any company that doesn’t do that won’t be in business long,” Prince said. But in an email, he added: “We have a deep and abiding respect for our users’ privacy, disclose to our users whenever possible if we are ordered to turn over information and would fight an order that we believed was not proper.”


Juliannne Sohn, an FBI spokeswoman, declined to comment.


Michael Sussmann, a former Justice Department lawyer who prosecuted computer crimes, said U.S. law enforcement agencies may in fact prefer that the Web’s most wanted are parked behind CloudFlare rather than a foreign service over which they have no jurisdiction.


Federal investigators “want to gather information from as many sources as they can, and they’re happy to get it,” Sussmann said.


In an era of rampant cyber warfare, Prince acknowledged he is something of a war profiteer, but with a wrinkle.


“We’re not selling bullets,” he said. “We’re selling flak jackets.”


(Reporting By Gerry Shih in San Francisco and Nidal al-Mughrabi in Gaza; editing by Jonathan Weber and Claudia Parsons)


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“Lincoln” leads Golden Globe movie nominations






LOS ANGELES (Reuters) – “Lincoln,” the tale of U.S. President Abraham Lincoln‘s battle to end slavery, ruled at the Golden Globe nominations on Thursday, while a very different movie take on slavery – “Django Unchained” – got a big boost in Hollywood’s crowded awards season.


Steven Spielberg’s portrayal of one of America’s most revered presidents won a leading seven nominations, including best drama, best director, best screenplay and best actor for Daniel Day-Lewis in the title role.






But “Lincoln” faces stiff competition at the Golden Globes from Ben Affleck’s Iran hostage drama “Argo” and Quentin Tarantino‘s dark and quirky slavery-era Western, “Django Unchained.”


The best drama nominees were rounded out by thriller “Zero Dark Thirty” about the hunt for Osama bin Laden, with four mentions, and the shipwreck tale, “Life of Pi,” with three.


The Golden Globe Awards, which will be given out by about 80 members of the Hollywood Foreign Press Association (HFPA) on January 13, are among the most widely watched honors programs leading up to the Oscars in February, although their ultimate choices for best movie rarely coincide.


‘LINCOLN’ SEEN AS OSCAR FRONTRUNNER


“Lincoln” is already regarded as an Oscar frontrunner after picking up multiple accolades from U.S. critics’ groups and the Screen Actors Guild (SAG).


Producer Kathleen Kennedy said the film’s portrayal of Lincoln’s battles in Congress to get slavery abolished had struck a chord with Americans at a time of political gridlock in Washington.


“People have become frustrated with the political process, and the movie takes you on a journey that shows the democratic process is difficult but the end result is a very satisfying process…I think that’s what people are excited about after watching ‘Lincoln,’” Kennedy told Reuters on Thursday.


Tarantino’s violent and sometimes comic “Django Unchained,” starring Jamie Foxx, has fared less well – until now.


“This was a huge boost. ‘Django Unchained‘ was very much SAG snubbed. But now they are really back in the game,” Thelma Adams, contributing editor at Yahoo! Movies, told Reuters.


“It’s very gratifying to get this many nominations from the HFPA for a film I worked so hard on and am so passionate about,” Tarantino said in a statement.


Unlike the Academy Awards, the HFPA has separate categories for film dramas and comedies.


“Les Miserables,” the movie version of the worldwide hit stage musical, earned four Golden Globe nominations in the comedy/musical category, as did “Silver Linings Playbook,” about an unlikely romance between a man suffering from bipolar disorder and a young widow.


The stars of both films – Hugh Jackman and Anne Hathaway for “Les Miserables,” and Jennifer Lawrence and Bradley Cooper for “Silver Linings Playbook,” – will be among those competing for acting awards.


FROM STAGE TO SCREEN


“Les Mis” director, Tom Hooper, who failed to get a nomination for his work on the movie, acknowledged the challenge of translating the beloved musical to the big screen.


“Millions of people hold this musical so close to their heart. I had to make a film that honors that experience…and I needed to find a way to work, which is why I chose to do all live singing,” Hooper told Reuters.


The HFPA also opened the door to smaller, sometimes overlooked movies and performances, while largely snubbing high profile contenders such as the James Bond film “Skyfall,” which got just one mention, for Adele’s best original song.


Wes Anderson’s “Moonrise Kingdom” and admired British senior ensemble film, “The Best Exotic Marigold Hotel,” were both nominated in the best musical or comedy category.


“They are precious little films that now have to be taken seriously,” said Tom O’Neil of awards website Goldderby.com.


In the acting race, Jessica Chastain’s CIA agent in “Zero Dark Thirty” will square off against Helen Mirren in “Hitchcock,” British actress Rachel Weisz in period drama, “The Deep Blue Sea,” France’s Marion Cotillard for “Rust and Bone,” and Naomi Watts in tsunami survival tale “The Impossible.”


Chastain said that aside from being a true-life thriller, “Zero Dark Thirty” also aimed at asking questions about society.


“To be involved in a movie that does that – the 9/11 hunt for Osama bin Laden pretty much defined this decade for us – and to be playing the woman who sacrificed so much to find him is such an honor,” the actress told Reuters.


Day-Lewis’s performance as Lincoln will compete against Denzel Washington’s alcoholic airline pilot in “Flight,” Richard Gere’s role as a corrupt financial executive in “Arbitrage,” John Hawkes as a severely disabled man in “The Sessions,” and Joaquin Phoenix’s drifter in the cult tale, “The Master.”


The Golden Globes also honor the year’s best TV shows. “Game Change,” the HBO film about Sarah Palin’s 2008 bid to become U.S. vice-president, led the nominations with five, followed by post-9/11 psychological thriller, “Homeland,” with four.


(Additional reporting by Piya Sinha-Roy and Eric Kelsey; Editing by Paul Simao and David Brunnstrom)


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In challenge to personalized cancer care, DNA isn’t all-powerful






NEW YORK (Reuters) – The cancer cells were not behaving the way the textbooks say they should. Some of the cells in colonies that were started with colorectal tumor cells were propagating like mad; others were hardly multiplying. Some were dropping dead from chemotherapy and others were no more slowed by the drug than is a tsunami by a tissue. Yet the cells in each “clone” all had identical genomes, supposedly the all-powerful determinant of how cancer cells behave.


That finding, published online Thursday in Science, could explain why almost none of the new generation of “personalized” cancer drugs is a true cure, and suggests that drugs based on genetics alone will never achieve that holy grail.






Scientists not involved in the study praised it for correcting what Dr. Charis Eng, an oncologist and geneticist who leads the Genomic Medicine Institute at the Cleveland Clinic, called “the simple-minded” idea that tumor genomes alone explain cancer.


Calling the study “very exciting,” she said the finding underlines that a tumor’s behavior and, most important, its Achilles heel depend on something other than its DNA. Her own work, for instance, has shown that patients with identical mutations can have different cancers.


The core premise of the leading model of cancer therapy is that cells become malignant when they develop mutations that make them proliferate uncontrolled. Find a molecule that targets the “driver” mutation, and a pharmaceutical company will have a winner and patients will be cancer-free.


That’s the basis for “molecularly targeted” drugs such as Pfizer’s Xalkori for some lung cancers and Novartis’s Gleevec for chronic myeloid leukemia. When those drugs stop working, the dogma says, it is because cells have developed new cancer-causing mutations that the drugs don’t target.


In the new study, however, scientists found that despite having identical genetic mutations, colorectal cancer cells behaved as differently as if they were genetic strangers. The findings challenge the prevailing view that genes determine how individual cells in a solid tumor behave, including how they respond to chemotherapy and how actively they propagate.


If DNA is not the sole driver of tumors’ behavior, said molecular geneticist John Dick of the Princess Margaret Cancer Centre in Toronto, who led the study, it suggests that, to vanquish a cancer entirely, drugs will have to target their non-genetic traits too, something few drug-discovery teams are doing.


Genomes are what cutting-edge clinics test for when they try to match a patient’s tumor to the therapy most likely to squelch it.


For their study, Antonija Kreso, Catherine O’Brien and other scientists under Dick’s direction took colorectal cancer cells from 10 patients and transplanted them into mice. They infected the cells with a special virus that let them track each cell, even after it divided and multiplied and was transplanted into another mouse, then another and another, through as many as five such “passages.”


Only one in 10,000 tumor cells was responsible for keeping the cancer growing, the scientists found – in some cases for 500 days of repeated transplantation from one mouse to the next. Genetically-identical tumor cells stopped dividing within 100 days even without treatment.


Tumor cells that were not killed by chemotherapy – the scientists used oxaliplatin, a colon-cancer drug sold by Sanofi as Eloxatin – had the same mutations as cells that were. The survivors tended to be dormant, non-proliferating ones that suddenly became activated, causing the tumor to grow again. Yet the cells – dormant or active, invulnerable to chemo or susceptible – had identical genomes.


“I thought we’d be able to look at the genetics that let some cells propagate, or not be susceptible to chemotherapy, but lo and behold there was no genetic difference,” said Dick. “That goes against a main dogma of the cancer enterprise: that if a tumor comes back after treatment it’s because some cells acquired mutations that made them resistant.”


That’s true in some cases, he said, “but what our data are saying is, there are other biological properties that matter. Gene sequencing of tumors is definitely not the whole story when it comes to identifying which therapies will work.”


The results were surprising enough, Dick said, that experts reviewing the paper for Science asked him to run additional tests to make sure the cells that behaved so differently were in fact genetic twins. He did, they were, and Science accepted the paper.


Other experts also praised the work, saying it supported the growing suspicion in the field that personalized cancer therapy is oversimplistic, at least in how it’s sold to the public.


“It’s not as simple as just sequencing mutations to tailor therapies to each tumor,” said surgical oncologist Dr. Steven Libutti of the Montefiore Einstein Center for Cancer Care in New York City. “In my mind, the findings are not unexpected. Other things besides genes matter: the environment in which a tumor is growing, for instance, plays an important role in whether therapy will be effective.”


Rather than targeting DNA alone, the Toronto scientists suspect, effective therapies would also take aim at what phase of its cycle a cell is in (dormant, growing or dividing, for example), which of its genes are activated, whether it sits in a region of the tumor that is starved of oxygen, and other non-genetic properties.


Nudging tumor cells out of their dormant phase and into their growth cycles, for instance, could make them more susceptible to chemotherapy, which generally targets rapidly dividing cells.


“Our findings raise questions about the resources put into sequence, sequence, sequence,” said Dick. “That has led to one kind of therapeutic” – molecularly-targeted drugs – “but not the cures the public is being promised.”


(Reporting by Sharon Begley; editing by Claudia Parsons)


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