Amgen experimental drug lowers cholesterol in mid-stage trial
















LOS ANGELES (Reuters) – Amgen Inc‘s experimental drug AMG145 reduced levels of bad cholesterol by as much as 55 percent in combination with statin drugs in patients genetically predisposed to high cholesterol, according to data from a midstage trial presented on Monday.


The new drug, given by injection every four weeks, is part of a promising new class of biotech medicines known as PCSK9 inhibitors designed to target a protein that prevents the body from removing artery blocking LDL cholesterol from the bloodstream.













Statins, such as Pfizer Inc‘s Lipitor and AstraZeneca’s Crestor, work by preventing the liver from making cholesterol.


The Phase II trial found that after 12 weeks, patients treated with a low dose of AMG145 had a 43 percent reduction in LDL, while those given a higher dose had a drop of 55 percent. Patients treated with a placebo saw a 1 percent increase in LDL cholesterol.


The trial, presented here at the annual scientific meeting of the American Heart Association, included 168 patients with heterozygous familial hypercholesterolemia, in which a defective gene inherited from one parent impairs the ability to properly metabolize LDL. The disorder is estimated to affect about one in 500 people and causes extremely high cholesterol.


The most common side effects seen in the trial were injection-site reactions, cold-like symptoms and headache.


AMG145, along with other PCSK9 inhibitors being developed by companies like Pfizer, Regeneron Pharmaceuticals Inc in partnership with Sanofi and Roche, is a man-made antibody.


(Reporting By Deena Beasley; Editing by Bernard Orr)


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France urged to cut labour costs

















France’s President Francois Hollande is under pressure to reform its flagging economy after both the IMF and a separate government-commissioned report urged him to slash employment costs.













The International Monetary Fund said France must act or risk falling further behind its European peers.


The former boss of aerospace group EADS, Louis Gallois, urged the government to improve competitiveness.


Mr Gallois wants French payroll taxes cut by 30bn euros (£24bn) in two years.


Mr Gallois was asked by President Francois Hollande to investigate what was holding France back, as part of a “competitiveness pact”, looking at why the French economy has fallen behind rivals such as Germany and suggesting reforms that could help address the gap.


France accounts for just 13% of eurozone exports, compared with 17% a year ago, and its unemployment rate stands at 10.2%, as against Germany’s 6.9%.


The report’s 22 proposals include slashing the social contributions paid by employers by 20bn euros (£16bn), as well as those paid by employees by 10bn euros.


To recoup some of these lost funds, the report suggests increasing VAT and making cuts to public spending.


Mr Gallois also suggests the creation of a set of laws to make the creation of start-up businesses easier.


Growth ‘overshadowed’


Similarly, the IMF, in its annual review of the French economy, said France should ease employment laws to make it easier to both hire and fire workers, as well as cut payroll taxes to encourage employers to hire more staff.


The IMF also suggested the government should make working hours more flexible, limit future rises in the minimum wage and reduce unemployment benefits during economic upturns to provide a greater incentive to look for work.


“[France's] growth outlook is being overshadowed by a significant loss of competitiveness,” the IMF said.


Last month, the IMF cut its growth forecasts for Europe’s second-largest economy to 0.1% this year and 0.4% in 2013, from 0.3% and 0.8% respectively.


President Hollande, whose official response to the Gallois report is due on Tuesday, insisted he would take “tough decisions”, but said his policy needed to be “holistic”.


The government has already made clear that it will not contemplate shifting more of the tax burden on to households when it has already drastically cut spending, in a bid to reduce its 2013 deficit to 3% of gross domestic product (GDP) from 4.5%.


An indication of the report’s likely reception came from Social Economy Minister Benoit Hamon.


“This report is a contribution. It’s the government that governs,” he said.


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Will Ferrell Will Do Anything to Get You to Vote in Comedic PSA [VIDEO]

























GIve you a tattoo, eat underpants and human toenails, punch himself in the face … These are just a few of the things that Will Ferrell will do to get you to vote in Tuesday’s U.S. election.


[More from Mashable: Chris Rock Is Voting for the Whitest Candidate [VIDEO]]





















In a roughly minute-long YouTube video, the comedian shares a laundry list of tasks he will perform, ranging from the mundane to the bizarre.


Viewers can apparently hold Ferrell to his promise, as he proclaims, “I’m not kidding.”


[More from Mashable: John F. Kennedy Calls on Public to Vote [VIDEO]]


He concludes the video, posted to Barack Obama’s official YouTube page, by endorsing the president.


Will you heed Ferrell’s call to action? Tell us in the comments below.


Thumbnail image courtesy of Eva Rinaldi Photography


This story originally published on Mashable here.


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What election? Sandy’s the big story on ‘SNL’

























NEW YORK (AP) — You wouldn’t have known it was the Saturday before the election on “Saturday Night Live.”


Sure, Mitt Romney, played by Jason Sudeikis, made a quick appearance on “Weekend Update,” but otherwise much of the focus was on Superstorm Sandy — and Mayor Michael Bloomberg‘s sign-language interpreter, Lydia Callis.





















The real Callis has gained some pop-culture popularity with her enthusiastic interpreting of Bloomberg’s words. She was back at the mayor’s side at Saturday’s briefing in New York and was played on “SNL” by Cecily Strong. The mayor — played by Fred Armisen — thanked Callis for bringing “pizazz” to her job.


Hosting Saturday’s show was comedian and TV star Louis C.K. He said in the monologue of New York City: “We’re still standing.”


President Barack Obama didn’t appear on the show.


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Sanofi considered moving headquarters abroad: report

























PARIS (Reuters) – Sanofi‘s management considered moving its headquarters abroad in the last few months but the plan was nixed by the drugmaker’s chairman, French weekly Le Journal du Dimanche reported on Sunday, citing sources close to the board.


First mooted in July, when the Socialist government was preparing to introduce a 75 percent tax on top earnings, the plan envisaged moving the headquarters to London or the United States, or at least relocating Chief Executive Chris Viehbacher and his closest associates abroad.





















However, Chairman Serge Weinberg vetoed the project, the newspaper said, saying that Viehbacher had not raised the issue with him.


A Sanofi spokesman denied such plans were discussed and said the company’s recent move to new corporate headquarters in Paris showed its commitment to its base in the city.


Several of the company’s top executives are foreign and spend most of their time travelling abroad.


In addition to German-Canadian Viehbacher, they include Elias Zerhouni, an Algerian-born American in charge of research and development, and Hanspeter Spek, the German-born president of global operations.


Italian Roberto Pucci, senior vice president of human resources, and Karen Linehan, Sanofi’s American-born general counsel, are also part of the executive committee.


Sanofi, which is reshuffling its French research operations at a cost of around 900 jobs, would not be the first French firm to consider moving top executives overseas.


French industrial conglomerate Schneider Electric has kept its headquarters near Paris, but its top managers, including Chief Executive Jean-Pascal Tricoire, relocated to Hong Kong last year in a move to be closer to fast-growing markets in Asia.


Industry Minister Arnaud Montebourg, who has opposed the reorganization of Sanofi’s research activities in France, was cited by the newspaper as saying he hoped the plan was just a rumor.


(Reporting by Elena Berton; Editing by Hugh Lawson)


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Apple paid only 2% tax outside US


























Apple paid less that 2% corporation tax on its profits outside the US, its filing with US regulators has shown.





















Apple paid $ 713m (£445m) in the year to 29 September on foreign pre-tax profits of $ 36.8bn (£23.0bn), a rate of 1.9%.


It is the latest company to be identified as paying low rates of overseas tax, following Starbucks, Facebook and Google in recent weeks.


It has not been suggested that any of their tax avoidance schemes are illegal.


All of the companies do pay considerable amounts of other taxes in the UK such as National Insurance and raise large sums of VAT.


Apple’s figures for foreign tax appear on page 61 of its form 10k filing with the Securities and Exchange Commission (SEC).


It had paid a rate of 2.5% the previous year.


Apple channels much of its business in Europe through a subsidiary in the Republic of Ireland, which has lower corporation tax than Britain.


But even Ireland charges 12.5%, compared with Britain’s 24%.


Many multinational companies manage to pay substantially below the official corporation tax rates by using tax havens such as Caribbean islands.


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Anna Breslaw’s 600-Word Sprint: On New York, Facebook and the Superstorm

























TakePart is happier than ever to present “Anna Breslaw’s 600-Word Sprint,” a weekly column of social justice insight, provocation and solution. Look for Anna’s Sprint every week on the homepage of TakePart.



By the time the number of years you’ve lived in New York could make up (or surpass) the age of a toddler, you’re well acquainted with the fizzy aperitif of panic and preparation before a projected natural disaster. Having seen multiple false alarms, you’re also duly skeptical that anything is actually going to happen just because some weatherman Tweeted about it.





















Nevertheless, you make it to the store at the last minute and buy some water and crackers and a flashlight and cat food. Or—as I spent last year’s overhyped Hurricane Irene—you go to a friend’s house in Chelsea and watch all of Twin Peaks and sleep far away from the windows.


Obviously, in the case of Monday night, the event was actually of severe magnitude—85 dead and rising, millions still without power, possibly $ 50 billion in financial losses (figure is still in estimates)—and the Tri-State Area will undoubtedly be dealing with the consequences for months. In short, I thought it was going to be like this, but it was like this.


MORE: Hurricane Sandy Recovery: How to Help


However, along with the damage incurred by the storm comes a camaraderie you don’t usually see around these parts. And, because we live in the future, it’s primarily communicated via social media.


Photos of good Samaritans placing power strips outside their houses for strangers to charge their phones are making the rounds, and people with power are inviting their Facebook friends over for food and Wi-Fi.


“We are ok” was the most-shared term on Facebook as of 10 a.m. Eastern time on Tuesday morning. Others in the Top 10 included “power” (lost power, have power), “made it” and “safe.”


Photos of good Samaritans placing power strips outside their houses for strangers to charge their phones are making the rounds, and people with power are inviting their Facebook friends over for food and Wi-Fi.


At the grocery store Monday afternoon, a woman and I nervously chatted in the endless checkout line about unperishable almond milk for her baby—just in case. I held her place in line as she went to grab it and asked if she could get me two Greek yogurts. This may not seem terribly significant anywhere but New York, where talking to strangers sans inebriation is tantamount to immediate exile from the borough.


(Of course, one can’t help but wonder what the sociological response would have been if—God forbid—it had been even worse. Just think of every major disaster anecdote or film you know: There’s the looting scene, someone smashing a TV set into the window of a store, and people being trampled to death in a rush, which has happened in far less dire conditions than these. Fortunately, there’s no need to think too hard about it this time.)


As for those in Sandy’s path fortunate enough not to incur any major individual loss, we’re basically just left with a whole lot of rebuilding and an abiding sense of plain weirdness: The rumors of alligators swimming in the streets of a decimated Atlantic City, for one thing. This shirtless dude jogging through the storm with a horse mask on. This new temporary subway map, reminding us that even the steadfast MTA system is mortal. And so on.


Nevertheless, we persevere; at least, as much as we can without leaving our borough.


And if anyone wants to come over, I have power and crackers.


Do you have power and crackers, or anything comparable, to share? Leave it in COMMENTS.


Related Stories on TakePart:


• Anna Breslaw’s 600-Word Sprint: Is Wonder Woman Necessary?


• (VIDEO) Strength in Disaster: Courageous Young Vets Rebuild Alabama Town Devastated by the Storms


• Anna Breslaw’s 600-Word Sprint: The Oxymoronic Rise of Anti-Rape Zealotry



Anna Breslaw is a regular contributor to Jezebel, New York magazine’s Vulture and Glamour, and her writing has been featured elsewhere. She lives in Brooklyn. Email Anna | Anna’s Tumblr


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AP PHOTOS: Stars come out for Sandy victims’ show

























NEW YORK (AP) — For the victims of Superstorm Sandy, it was a sorely needed message delivered.


From “Livin’ on a Prayer” to “The Living Proof,” every song Friday at NBC’s benefit concert became a message song.





















New Jersey‘s Jon Bon Jovi gave extra meaning to “Who Says You Can’t Go Home.” Billy Joel worked in a reference to Staten Island, the decimated New York City borough.


The hourlong event, hosted by Matt Lauer, was heavy on stars and lyrics identified with New Jersey and the New York metropolitan area, which took the brunt of this week’s deadly storm. The telethon was a mix of music, storm footage and calls for donations from Jon Stewart, Tina Fey, Whoopi Goldberg and others.


The show ended, as it only could, with Bruce Springsteen and the E Street Band, tearing into “Land Of Hope and Dreams.”


“God bless New York,” Springsteen, New Jersey‘s ageless native son, said in conclusion. “God bless the Jersey shore.”


Here, in pictures, are some of the performers on this somber but hopeful night:


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How Computational Models Are Improving Medicine [Video]

























Click here to view the video


High-resolution electromechanical model of a heart; courtesy of N. Trayanova




















The more we learn about cancer, heart disease and Alzheimer’s, the more vexingly complex they seem–and the more elusive their cures. Even with cutting-edge imaging technology, biomarker tests and genetic data, we are still far from understanding the multifaceted causes and varied developmental stages of these illnesses. With the advent of powerful computing, better modeling programs and a flood of raw biomedical data, researchers have been anticipating a leap forward in their abilities to decipher the intricate dynamics involved human disease. Now, these computational capabilities are starting to arrive, according to a new analysis published online this week in Science Translational Medicine. In fact, “the field has exploded,” Raymond Winslow, director of the Johns Hopkins Institute for Computational Medicine, and co-author of the review, said in a prepared statement. Medicine and medical research largely have been focused on small specialties and narrow studies. But the body is a whole system–not isolated organ groups–and it is in constant interaction with the wider environment, including pollutants, toxins and other stressors. The resulting interactions do not only work in a single direction; instead, we have learned that there are feed-forward and feedback loops and crosstalk on cellular, molecular and genetic levels. This nexus is where advances in computational medicine are poised to make a large contribution. “Computational medicine can help you see how the pieces of the puzzle fit together to give a more holistic picture,” Winslow said. “We may never have all of the missing pieces, but will wind up with a much clearer view of what causes disease and how to treat it.” Models comparing gene expression in different patients have already successfully helped to determine different grades of prostate cancer, predict how different patients will respond to breast cancer treatment and find different types of stomach cancer. Scientists are also taking advantage of more advanced anatomical data to model whole organs and their function–and dysfunction. Using, for example, diffusion tensor magnetic resonance imaging, researchers can collect detailed information about heart anatomy, fiber and structure. This macro structure can be combined with more cellular-based models for “unprecedented structural and biophysical detail, including cardiac electromechanics,” the researchers noted in their paper. With this information, scientists are learning more about blood-flow dynamics, arrhythmia and heart attacks. These new models are now starting to be translated back to individual patients, to help find better treatments. Computational-medicine algorithms from detailed brain maps have already been used to develop an iPad app that is being used clinically to help doctors decide on deep brain stimulation locations and strengths. These models, however, also need to be checked frequently against real-world data and adjusted accordingly. But researchers who are armed to deal with this once unusual cross-discipline endeavor are growing more common. “There is a whole new community of people being trained in mathematics, computer science and engineering, and they are being cross-trained in biology,” Winslow said. “This allows them to bring a whole new perspective to medical diagnosis and treatment.” The myriad applications for computational medicine approaches are only beginning to be explored, the researchers noted. “As we gain confidence in the ability of computational models to predict human biological processes, they will help guide us through the complex landscape of disease, ultimately leading to more effective and reliable methods for disease diagnosis, risk stratification and therapy,” the researchers wrote. “We are poised at an exciting moment in medicine.”

Video of electromechanical heart model courtesy of N. Trayanova


Follow Scientific American on Twitter @SciAm and @SciamBlogs. Visit ScientificAmerican.com for the latest in science, health and technology news.
© 2012 ScientificAmerican.com. All rights reserved.


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Syria army quits base on strategic Aleppo road

























BEIRUT (Reuters) – The Syrian army abandoned its last base near the northern town of Saraqeb after a fierce assault by rebels, further isolating the strategically important second city Aleppo from the capital.


But in a political setback to forces battling to topple President Bashar al-Assad, the United Nations said the rebels appeared to have committed a war crime after seizing the base.





















The opposition Syrian Observatory for Human Rights said on Friday government troops had retreated from a post northwest of Saraqeb, leaving the town and surrounding areas “completely outside the control of regime forces”.


It was not immediately possible to verify the reported army withdrawal. Authorities restrict journalists’ access in Syria and state media made no reference to Saraqeb.


The pullout followed coordinated rebel attacks on Thursday against three military posts around Saraqeb, 50 km (30 miles) southwest of Aleppo, in which 28 soldiers were killed.


Several were shown in video footage being shot after they had surrendered.


“The allegations are that these were soldiers who were no longer combatants. And therefore, at this point it looks very likely that this is a war crime, another one,” U.N. human rights spokesman Rupert Colville said in Geneva.


“Unfortunately this could be just the latest in a string of documented summary executions by opposition factions as well as by government forces and groups affiliated with them, such as the shabbiha (pro-government militia),” he said.


Video footage of the killings showed rebels berating the captured men, calling them “Assad’s dogs”, before firing round after round into their bodies as they lay on the ground.


Rights groups and the United Nations say rebels and forces loyal to President Bashar al-Assad have committed war crimes during the 19-month-old conflict. It began with protests against Assad and has spiraled into a civil war which has killed 32,000 people and threatens to drag in regional powers.


The mainly Sunni Muslim rebels are supported by Sunni states including Saudi Arabia, Qatar and neighboring Turkey. Shi’ite Iran remains the strongest regional supporter of Assad, who is from the Alawite faith which is an offshoot of Shi’ite Islam.


STRATEGIC BLOW


Saraqeb lies at the meeting point of Syria’s main north-south highway, linking Aleppo with Damascus, and another road connecting Aleppo to the Mediterranean port of Latakia.


With areas of rural Aleppo and border crossings to Turkey already under rebel control, the loss of Saraqeb would leave Aleppo city further cut off from Assad’s Damascus powerbase.


Any convoys using the highways from Damascus or the Mediterranean city of Latakia would be vulnerable to rebel attack. This would force the army to use smaller rural roads or send supplies on a dangerous route from Al-Raqqa in the east, according to the Observatory’s director, Rami Abdelrahman.


In response to the rebels’ territorial gains, Assad has stepped up air strikes against opposition strongholds, launching some of the heaviest raids so far against working class suburbs east of Damascus over the last week.


The bloodshed has continued unabated despite an attempted ceasefire, proposed by join U.N.-Arab League envoy Lakhdar Brahimi to mark last month’s Muslim holiday of Eid al-Adha.


In the latest in a string of fruitless international initiatives, China called on Thursday for a phased, region-by-region ceasefire and the setting up of a transitional governing body – an idea which opposition leaders hope to flesh out at a meeting in Qatar next week.


Veteran opposition leader Riad Seif has proposed a structure bringing together the rebel Free Syrian Army, regional military councils and other rebel forces alongside local civilian bodies and prominent opposition figures.


His plan, called the Syrian National Initiative, calls for four bodies to be established: the Initiative Body, including political groups, local councils, national figures and rebel forces; a Supreme Military Council; a Judicial Committee and a transitional government made up of technocrats.


The initiative has the support of Washington. U.S. Secretary of State Hillary Clinton called on Wednesday for an overhaul of the opposition, saying it was time to move beyond the troubled Syrian National Council.


The SNC has failed to win recognition as the legitimate representative of the Syrian people and Clinton said it was time to bring in “those on the front lines fighting and dying”.


(Additional reporting by Oliver Holmes in Beirut and Stephanie Nebehay in Geneva; Editing by Jon Boyle)


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